The noise comes from Futurama, the animated sitcom created by Matt Groening that premiered in 1999. Dr. Zoidberg, the incompetent alien doctor at Planet Express, makes the sound while scuttling away, a vocal homage to Curly Howard of The Three Stooges. Clips of the escape were shared widely as reaction videos and on soundboards, separating the woop from full episodes. Its short length and clear meaning kept it popular for memes about fleeing trouble, long after the show ended its original runs.
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Dr. Zoidberg's famous scuttle noise from Futurama, used as a funny reaction sound for quick escapes, awkward exits and silly panic moments in memes.
Dr. John Zoidberg makes this frantic woop woop woop noise in Futurama whenever he scuttles sideways out of a scene like a startled crab. Voiced by Billy West, the sound speeds up in a rising, rubbery rhythm that matches his flailing claws and panicked run. It is not a word so much as a pure escape noise, instantly signalling cowardice, excitement or gleeful nonsense. On a video it turns an ordinary exit into a joke, because viewers hear the panic before they fully process what the character is running from.