Place it as the final reaction beat after the offending photo, message or clip has been shown in full. Follow it with a hard cut to the next scene, or precede it with a disgusted reaction sound so the reply reads as the closing line.
Over dit geluid
This is a 2.1-second voice clip of Homero delivering a crude Spanish insult, with the swearing clipped into the shorthand 'chtm pta asquerosa.' The delivery lands as disgusted and fed up, turning a quick Homer reaction into a blunt, rude comeback that feels funny because it is so over-the-top for such a short burst.