Put it immediately after the annoying action peaks, so it closes that beat before the next scene starts. For a longer reaction, lead in with No No Wait Wait as the warning, then let this clip answer it, and finish with Damn for a final beat.
Over dit geluid
This is a 1.6-second Portuguese voice clip in which a man says “Isso me irrita!”, meaning “That irritates me!”, in a flat, fed-up tone. It feels instantly relatable and lightly comic, like a sigh of annoyance turned into a punchline, and it works because the irritation sounds genuine rather than performed.