Totally Not Roxanne spread as a short reaction clip on soundboards, where the joke is the denial itself rather than any backstory. Creators reuse it whenever a person, character, or pet is obviously guilty but acting innocent, which makes it work across gaming clips, anime edits, and everyday group chat jokes. Because the name is specific but the situation is universal, viewers understand it instantly even without context. Its lasting appeal is that simple, suspicious confidence, which fits almost any failed cover story or awkward reveal online today.