George Cooper Sr., played by Lance Barber, is Sheldon Cooper's father in Young Sheldon, the Big Bang Theory prequel that ran from 2017 to 2024. His plainspoken, put upon dad reactions became easy meme material, and short lines like this oh no were clipped and shared on soundboards and social videos. Like the oh my god meme, it survives because it expresses instant dread in under two seconds, so creators reuse it for fails, bad news and family mishaps without needing any setup or context from the show itself.