The Italian phrase translates as the last remaining neuron, and it is used online as shorthand for a brain worn out by long study, especially maths. Rather than coming from one well-known scene, it works as a relatable caption for that moment when concentration collapses and only a single thought seems to remain. Student creators and Italian meme pages have kept it in circulation by pairing it with exam stress, homework overload, and late-night revision, where the exaggeration turns exhaustion into something funny instead of frustrating.