Red Dead Redemption 2 was released by Rockstar Games in 2018, following outlaw Arthur Morgan in the American frontier in 1899. Midway through the story Arthur is diagnosed with tuberculosis, and his worsening cough becomes a recurring, dreaded sound in missions and free roam. Clips of the cough were later lifted to soundboards and short video edits, where players use it out of context for illness jokes and dramatic reactions, turning a serious story detail into a familiar gaming meme.
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The RDR2 cough sound effect from Red Dead Redemption 2, featuring Arthur Morgan's harsh tuberculosis fit used for sick, dying or dramatic meme edits.
This is a prolonged, rough coughing fit taken from Red Dead Redemption 2, the kind Arthur Morgan breaks into as his illness gets worse. It starts with a tight wheeze, builds into several deep chesty coughs, and trails off into strained breathing. The performance sounds genuinely unwell rather than cartoonish, which makes it instantly recognisable to players. Dropped into a video it signals sickness, exhaustion or a character dramatically falling apart, and the length lets the discomfort hang long enough to land as either a serious beat or an uncomfortable joke.