Critical Mission Failure is the game over message and cue from Mass Effect, BioWare's science fiction role playing series that began in 2007. Players saw it whenever Commander Shepard died or a key objective was lost, returning them to a previous save. The stark wording and bleak sting made the moment memorable beyond the game, and clips and edits later reused it online as a shorthand for any attempt that ends completely and irreversibly, from gaming wipes to everyday blunders shared as memes.