Like a Prayer was originally released by Madonna in 1989. The song became closely tied to Deadpool & Wolverine after being featured prominently in the 2024 Marvel film, including emotionally heightened action sequences. Choral and cinematic arrangements helped the track spread through superhero edits, reaction videos, and short-form memes. Its continuing appeal comes from the recognizable melody and the sharp contrast between reverent vocals, large-scale action, and Deadpool's comedy, allowing creators to make both sincere and absurd moments feel unusually grand.