Place it at the very end of an edit, right after the setup, so it lands as the final punchline. Follow it with the Bruh Sound Effect for a deadpan reaction, or lead into it with the Emotional Damage Meme Sound when the joke needs a bigger buildup.
About this sound
This clip is just under two seconds of one Portuguese voice speaking a single blunt sentence in a clear, exaggerated, playful way, with no music or background sound behind it. The effect is a sudden shock followed by laughter, because the crude wording is so direct and unexpected. It travels as a Brazilian meme audio used in group chats and short video edits.