The Game Over cue comes from Nintendo's Super Mario Bros. era and became one of the most recognizable failure sounds in video game culture. It spread far beyond gameplay through compilations, YouTube edits, livestreams and short memes, where it became a shorthand for losing or messing up. Its staying power comes from how quickly listeners understand the joke: a few notes instantly communicate defeat. In meme editing, it often fills the same role as a buzzer, but with a more playful retro feel.