Handle With Care was released by the Traveling Wilburys in 1988 as the opening track on their debut album, Traveling Wilburys Vol. 1, with George Harrison singing lead alongside Bob Dylan, Tom Petty, Jeff Lynne and Roy Orbison. Originally written as a B-side, it became the group's best-known song after its relaxed, collaborative sound caught on with radio listeners. Decades later, the track still circulates in fan edits, tribute videos and nostalgic playlists, where its gentle tone and famous supergroup lineup keep it instantly recognisable.