This sound is best known from Resident Evil 4, where Ashley Graham repeatedly calls out to Leon during danger and escort sections. The line became a lasting in-joke among players because of how often it can be heard in tense gameplay. Over time, fans clipped it into meme compilations, gameplay edits and parody videos. It still gets used because even people who have not finished the game recognise the dramatic delivery and the very specific feeling of being responsible for someone in trouble.