The exact source of this hey guys clip is not clearly identified from the available information, so it is best treated as a general voice sound rather than a confirmed quote from a specific show, game or creator. Sounds like this spread because they are easy to reuse in short edits, reaction videos and chat-style memes. A plain greeting becomes funny through timing alone, especially when it introduces something uncomfortable, chaotic or obviously off-topic, which keeps this kind of clip useful across many meme formats.