In the Ghetto was written by Mac Davis and became a 1969 hit for Elvis Presley, telling a bleak story of poverty in Chicago. South Park reused the song through Eric Cartman, who sings it to mock Kenny McCormick and other poor characters, turning the earnest chorus into a running insult. Clips of Cartman's version spread on soundboards and in meme edits because the melody is instantly familiar and the joke is clear even out of context, which keeps it in use for poverty gags.
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Eric Cartman singing In the Ghetto from South Park, his mocking Elvis cover used as a reaction sound for poor, run-down or awkward situations.
This is Eric Cartman delivering his deliberately awful version of In the Ghetto in his high, nasally voice over a simple backing. He stretches the line with smug, teasing emphasis, turning Elvis Presley's serious ballad about poverty into a childish taunt aimed at anyone living in rough conditions. The contrast between the somber original lyric and Cartman's gleeful delivery is what makes the clip land as comedy. It sounds instantly recognizable to South Park fans and works as a short, pointed punchline rather than a full song performance.