This sound comes from Resident Evil 4, the Capcom survival horror game in which Leon S. Kennedy fights the infected Ganado villagers of a rural Spanish village. The villagers shout in Spanish as they hunt him, and their aggressive cries became instantly recognisable to players. Clips of those shouts later spread through gaming soundboards, edits and reaction videos, where the raw delivery worked even for viewers who had never played the game. It remains popular because it instantly signals danger, pursuit and a tense, hostile encounter.