The clip comes from the Spanish dubbed version of The Simpsons, where Homer Simpson often loses his temper over minor setbacks in exaggerated fashion. His phrase me caguen is a rude, frustrated exclamation in Spanish, which is why Spanish speaking fans adopted it as a reaction sound. It circulated online alongside another Homer outburst from foreign dubs, and remains popular because the emotion is clear even without understanding every word. Creators still use it for relatable anger, bad luck and everyday disasters.