The line comes from the SpongeBob SquarePants episode No Hat for Pat, where the famously greedy Mr. Krabs, voiced by Clancy Brown, breaks character in a moment of panic and cries out for his grandmother. Short scream clips from the show travel fast because the exaggerated voice acting works without any context, and this one joined other SpongeBob scream memes such as the My leg fish clip. Editors also pair it with the SpongeBob sad song for fake-tragic edits. A decade and a half later it still circulates as a go-to reaction for helpless, comedic distress.