This line comes from Hinamatsuri, the comedy anime featuring Hina, a stoic girl with psychokinetic powers known for her emotionless reactions to chaos. Her phrase "ne, nani kore" became a shareable reaction clip among anime fans because it perfectly captures her character, unbothered and mildly puzzled instead of panicked. The snippet spread on soundboards and in fan edits where a short, deadpan Japanese question works better than an exaggerated English reaction for marking something odd or out of place.