The sound is listed from Pokemon Stadium, the Nintendo 64 battle game where Pokemon attacks were presented with larger, more dramatic effects than on handheld. Poison type moves have long relied on hissing gas and bubbling clouds to show damage that lingers after the hit, and this short clip captures that idea in audio form. Clips like it later circulated on soundboards for quick reuse, valued because the toxic meaning reads instantly in Let's Plays, battle reenactments, machinima and meme edits without needing any on screen explanation or dialogue.