Otis is the main character of Barnyard, the 2006 animated film that led to the Nickelodeon series Back at the Barnyard, which ran from 2007. The fun loving cow is known for loud, human like reactions, and short clips of his yells circulate as standalone reaction sounds. Online, editors lift the scream out of its cartoon context and reuse it for any panicked character, which is why it survives beyond the show as a quick shorthand for cartoon fear and comic overreaction in memes and edits.