Pinky and the Brain began as a recurring segment on Animaniacs before getting its own Warner Bros. animated series in 1995, starring two genetically enhanced laboratory mice. Each episode opened with Pinky asking Brain what they would do that night, a ritual that always led to another scheme for world domination. The greeting became shorthand for that nightly routine, and clips of it later circulated in cartoon compilations, reaction edits and meme videos. Its nostalgic pull and instantly familiar voices keep it useful for creators referencing classic nineties animation.