Resident Evil 4 was released in 2005, and its Ganados are the infected villagers who attack Leon Kennedy throughout the rural Spanish setting. Their screams were designed to sound human but distorted by infection, which is why they feel both familiar and wrong. Clips like this one spread through gameplay videos, horror compilations and meme edits, where editors reuse the scream outside the game to create instant tension. It remains popular because it is short, instantly recognisable to players, and works without context as a signal of danger.