Tuuuueuh circulates as a user shared soundboard clip with no confirmed original film, show or creator attached to it. Its appeal comes from how the drawn out spelling matches the strained sound itself, making it easy to search, share and recognise in a feed. Short cough and retch style clips like this became common in meme editing because they work as instant punctuation, replacing an explanation with a physical reaction. It is still used for sick jokes, gross outs and awkward moments where a blunt noise lands faster than dialogue.
About this sound
A short, harsh coughing burst stretched into a loud tuuuueuh grunt, used as a quick reaction sound for disgust, disbelief or a sudden sick joke.
Tuuuueuh is a very short, forceful cough that comes out more like a choked grunt than a normal clear of the throat. It starts abruptly, rises in a strained wheeze and cuts off just as quickly, which makes it feel exaggerated and a little gross on purpose. That harsh, bodily texture is the joke, because it instantly signals sickness, disgust or secondhand embarrassment without any words. Placed over a normal face or a bad moment, it turns the scene into slapstick and makes the reaction feel much bigger than the action that caused it.