The clip is best understood as a generic cartoon disappearance effect rather than a line from a named show or film. Short poof sounds like this have long been used in animation and comedy edits to signal that a ghost, magician or prankster has slipped away unseen. On soundboards it circulates as a quick, reusable gag for vanish moments, reaction videos and short-form clips, where its brevity matters more than any single origin. That flexibility is why it keeps appearing whenever a creator needs an instant, light-hearted disappearance.
About this sound
A short poof sound effect of a ghost vanishing into thin air, used in videos and memes when a character or object suddenly disappears from the scene.
This is a brief, cartoonish poof that suggests something has vanished in an instant. It opens with a soft whoosh, then a light puff, as if air has rushed in to fill the space where a ghost or character just stood. There is no voice or music, just that quick, airy disappearance, which makes it easy to read even on a phone speaker. On screen it sells the joke of someone being there one moment and gone the next, leaving viewers with a small surprise and a laugh rather than a dramatic scare. Its short length keeps the gag snappy and lets an editor cut to the reaction that follows.