Place it at the end of a short exchange, right after the overreaction it is answering, so the dismissal closes the scene. Put an Oh My God Wow reaction first, then let this clip answer it, and follow with a Damn reaction only if you want the reply to stay the last word.
About this sound
This is a very short French voice clip, lasting about a second and a half, built around the spoken phrase Rien à foutre. It feels blunt and unbothered, like a shrug in sound form, and it lands as dry humour rather than anger. The clip is tied to Vilebrequin, whose name appears in its title.