What the deuce is a catchphrase most associated with Stewie Griffin, the articulate baby voiced by Seth MacFarlane in the animated sitcom Family Guy, which premiered in 1999. Deuce was already old fashioned slang for the devil or confusion, and Stewie uses it whenever adults or rivals baffle him. Clips of the line circulated on forums, YouTube edits and soundboards during the 2000s and 2010s, becoming a shorthand reaction for stunned disbelief that still fits modern meme edits and short videos.