The phrase comes from the sitcom Diff'rent Strokes, where Gary Coleman played Arnold Jackson and made “Whatchu talkin' 'bout, Willis?” into a widely remembered TV catchphrase. The show aired from the late 1970s into the 1980s, and the line stayed alive through reruns, reaction clips, and internet memes. It remains popular because the wording is instantly recognizable and the meaning is universal: a funny way to call out something that sounds wrong, strange, or hard to believe.