No single video can claim this greeting, since 'What's up, YouTube' became the default opener for vloggers in the early 2010s and was repeated until it turned into a joke in itself. Imitations and parodies spread it across reaction channels and compilations, cementing it among classic meme intros that signal low-effort, high-energy content. Today creators use the line ironically as much as sincerely, and it circulates widely as a meme mp3 for editors who want an instantly recognisable hook without recording their own voice.