Place it at the peak of a fail or shock reveal, then follow it with a scream meme for a second hit before cutting to a reaction shot, and use an oh my god meme earlier to set up the surprise so the payoff lands harder.
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This clip is a single human voice holding a stretched 'aaaaiiaiiii aiiiii' yell for about thirteen seconds. It feels over-the-top and funny because the yell keeps going past the point where a normal reaction would stop, turning a simple shock into an exaggerated, cartoonish outburst.