This clip comes from Jesse Pinkman, played by Aaron Paul in the TV series Breaking Bad, which aired from 2008 to 2013. Jesse's habit of saying "bitch" became one of the character's most quoted traits, and short snippets spread widely in memes, reaction videos and soundboards. The line stays popular because it is instantly recognizable, extremely short and easy to drop at the exact beat of a joke. It often appears in the same kind of punchline edits as a shocked sound.