Put it at the end of a fail compilation as the closing reaction, after the biggest blunder, then follow it with a baby laughing meme for a softer finish or a cat laugh meme for a stranger one. For a messier edit, open with goofy ahh sounds before the fail, then let this clip close the sequence.
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This short clip, just over a second long, captures Derpy's bright, goofy laugh in a single burst. It feels silly, warm and a little clumsy, like catching someone laughing at their own mistake and pulling everyone else into the joke too.