Place it at the end of a loot-opening sequence, after the hopeful build-up and just before the reaction shot, then follow it with a Vine Boom for the failed reveal and a Dun Dun Dun to underline the bad luck.
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This 17-second sound effect is built around opening a chest and finding nothing inside, stretching that empty moment out until the disappointment has room to land. It feels anticlimactic and quietly funny, turning a missed reward into a small, awkward pause rather than a dramatic fail.