Place it as the final reaction after the bad take or bad news, not as an opener. Follow a shocked beat with the oh my god meme first, then answer with this clip, and close the sequence with the bruh soundboard button for a second, drier punch.
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This is a short 2.4-second voice clip of someone saying the French phrase 'J'en ai rien à foutre,' a blunt way of saying I do not care at all. It feels dismissive, fed up and darkly funny, the verbal shrug you give when you have completely checked out of a situation.