Place it in the middle of a spoken line, then follow it with the Shocked Meme Sound Effect to sell the reaction, and finish with Oh No No No Laugh once the speaker realises what slipped out.
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This is a sharp electronic beep lasting less than half a second, the flat high-pitched tone editors place over a swear word without breaking the sentence. It feels cheeky and funny, because listeners instantly know something rude was hidden and the gap makes the moment seem bigger than the word. It comes from television broadcast editing, where it masked profanity, and was adopted by YouTube creators for memes and videos.