Place it at the end of a failed-thought gag, after the setup has made the confusion clear, then follow it with a long brain fart for the slow realisation and emotional damage when the mistake sinks in.
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This 11-second meme clip plays on the joke that a person's brain has simply given up, turning a blank stare or a failed thought into a punchline. It feels absurd and self-deprecating, like admitting defeat before you have even tried to think.