Place it at the end of a roast exchange, after the setup line, then follow it with Bruh for the reaction and Emotional Damage for the aftermath, so the teacher line stays the centre of the scene.
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This is a short spoken clip, about six seconds long, of a teacher delivering the line 'your mom a hoe' in a teacher's voice. The bluntness lands as an awkward, jolting joke, funny because the insult comes from a teacher instead of a classmate, and it works best as a sudden comeback rather than a long exchange.