Place it at the end of a joke or fail edit, right after the reveal, then follow it with the Bruh sound for a deadpan contrast or the Baby Laughing Meme sound to keep the reaction going.
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This is a meme clip lasting just under 18 seconds, built around the name Toto and the French shorthand mdr for laughing out loud. It gives a light, silly, over-the-top laughing feeling, like a joke that keeps getting funnier the longer it goes on.