Place this clip at the very end of a reaction sequence as the payoff, after a build with the cat laugh meme and before a closing scream meme if you want a second reaction beat afterwards.
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This is an 11-second stretch of very loud human laughing that tips over into screaming, with both sounds overlapping and escalating together. It feels chaotic, unhinged and hysterically funny, the kind of meltdown laughter that sounds less like amusement and more like someone completely losing control.