Place it just after the line that sets up the smoking joke, so it lands as the payoff, then follow it with emotional damage for an exaggerated reaction and finish with a short bruh for a deadpan close.
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This roughly nine-second clip centres on one deeply gravelly, rasping voice, worn and rough in a way that sounds shaped by decades of heavy smoking. The harsh, croaky delivery is immediately striking, funny in its exaggeration and slightly uncomfortable to hear, which makes it land as a blunt, over-the-top reaction rather than a gentle aside.