No documented origin is supplied for this clip, so its background is best described through how the phrase is used online. Fam is informal slang for close family or friends, and ain't answering describes calls or messages going unanswered. As a soundboard clip, the phrase works as a short label for that situation, with the surrounding video supplying who was contacted and why. That flexibility helps explain its continued use: the same wording can fit a joke about a group chat, a missed call, or a friend who is offline, without needing extra context.