Place it at the reveal point of a short edit, after the setup caption has done its work. Follow it with the funny ha ha laugh sound button for the reaction beat, then cut back to the original scene without adding another meme hit.
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This clip is the niche meme sound known as Caca De Caine, marked in its title as a loud version for soundboard use. It gives a listener a jarring, over-the-top feeling, built for a reaction that is meant to feel excessive rather than subtle, funny because the volume and name do the work.