Gapers first appeared as low-level enemies in The Binding of Isaac, where their shuffling, gaping-mouthed design made them memorable despite their simple attacks. Their distinctive noises were later lifted from gameplay and shared on soundboards, where Isaac fans and meme creators could reuse them outside the game. The clip survives because it is short, instantly recognisable to players, and easy to drop into edits, streams and reaction videos whenever something gross, creepy or unexpectedly funny happens on screen.