Place it just after the setback is shown in a short edit, before the punchline lands. Start with the dramatic dun dun dun for tension, then let the crying carry the reaction, and finish with the anime wow as the final beat.
关于此声音
Over about 12 seconds, a young anime girl's voice collapses into sobs, catching on hiccups and uneven breaths as quiet whimpers swell into open wailing. The high, fragile delivery makes the upset feel urgent and larger than life. It leaves a listener with sadness, panic and embarrassment at once, so an ordinary disappointment suddenly plays as a dramatic, over-the-top collapse.