With no clear original source attached to the name, Brain Damage 101 spread as a generic reaction label on soundboards and in short-form edits. The 101 part plays on college course numbering, framing total confusion as if it were a class you could take. That simple framing made it easy to reuse for school jokes, gaming fails, chat memes and dumb moment compilations. It stays popular because it is short, instantly understood and does not need any context from a specific show or creator to work.