The clip spread through TikTok and short form video as a reaction sound during and after the Covid era, when exaggerated virus jokes became a common meme format online. Its appeal is the drawn out pronunciation, especially the rolled R in Birrrrus, which made it easy to reuse over unrelated coughing, sneezing or contamination scenes. It has remained in use as a shorthand for mock panic about germs, long after the original trend peaked, because the delivery alone signals the joke without needing context or explanation.