Place it right after the moment a bad decision is revealed, as the reaction that closes the scene. Follow it with Ah Shit Here We Go Again when the consequences begin, or lead into it with No God Please No when the choice is still being resisted.
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The clip is a short, weary spoken line from Deus Ex, delivered in a low, resigned voice over about two seconds. It lands as a dry protest against a decision forced on the speaker, mixing frustration with reluctant acceptance. The understated delivery makes it feel both dramatic and funny, perfect for moments when a plan goes wrong through no fault of your own.