Place it near the end of a skit, after the setup and just before the final reaction shot, so it acts as the payoff. Pair it with a gasp or a buzzer for a wrong answer, putting the gasp first, this clip second, and the buzzer last to close the joke.
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This is a brief meme clip built around the name Dr Ray, lasting under two seconds and centred on a single moment. It feels cheeky and knowing, like a quick aside from someone pretending to have all the answers, and it works best as a light, teasing reaction rather than a serious statement.