Place it at the end of a short skit, once the interruption has already been shown, so it lands as the payoff rather than the setup. Pair it with Bruh Meme beforehand to set up the interruption, or follow it with Fail Sound Meme when the other person gives up.
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This is a short spoken movie quote lasting about two and a half seconds, in which a man snaps the line 'I'm busy, stupid dick!' at someone interrupting him. The delivery is blunt, irritated and deliberately rude, which makes it feel funny rather than genuinely hostile when used out of context. It comes from the film Just Friends.