Place it at the end of a fail or blooper sequence, after the action has already landed, then follow it with the Baby Laughing Meme for a lighter payoff or the Cat Laugh Meme when the joke needs a sillier second beat.
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This four-second clip is a wheezy, breathless laugh that catches between gasps, with a strained, high-pitched wheeze running through each burst. It feels awkward and contagious at once, like laughing so hard that breathing becomes part of the joke, and it lands best as a sudden, exaggerated reaction to something unexpectedly funny.